Peer-reviewed veterinary case report
Identification of alpha-substituted acylamines as novel, potent, and orally active mGluR5 negative allosteric modulators.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2015
- Authors:
- Yoshikawa, Keita et al.
- Affiliation:
- Pharmaceutical Research Laboratories · Japan
Abstract
This Letter describes the identification of a series of novel non-acetylenic mGluR5 negative allosteric modulators based on the alpha-substituted acylamine structure. An initial structure-activity relationship study suggested that (R)-19b and (R)-19j might have good in vitro activity. When administered orally, these compounds were found to have an anxiolytic-like effect in a mouse model of stress-induced hyperthermia.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26112438/