Peer-reviewed veterinary case report
New genetic mutations found that affect dog lymphoma treatment
By Josephine Tsang et al.Ā·Published in npj Precision OncologyĀ·2025Ā·View original on Semantic Scholar ā
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Original publication title: Identification of novel genetic mutations for the treatment prognostication of canine lymphoma
- Species:
- dog
Plain-English summary
A study involving 238 dogs with lymphoma (a type of cancer) found that certain genetic mutations can affect how well dogs respond to chemotherapy. For example, dogs with mutations in the TRAF3 gene had better survival rates when treated for B-cell lymphomas, while those with mutations in PIK3CD and CREBBP had worse outcomes with T-cell lymphomas. This research suggests that understanding a dog's specific genetic makeup could help veterinarians choose the most effective treatment plan for lymphoma, potentially improving the chances of recovery.
People also search for: dog lymphoma treatment options Ā· canine cancer genetic mutations Ā· chemotherapy response in dogs with lymphoma
Abstract
Canine lymphoma, a phenotypically and genetically heterogeneous disease, represents a significant proportion of canine cancers. We present a large-scale study of 238 dogs with lymphoma to better understand the genetic landscape of canine lymphoma, as well as the relationship to clinical outcomes. Using a targeted next-generation sequencing panel comprising 308 genes, we screened somatic and germline mutations in matched tumor and normal samples. Our findings revealed key associations between genetic alterations and lymphoma subtypes, with certain somatic variants linked to significant differences in response to common chemotherapy regimens. Recurrent mutations in genes such as KMT2C, KMT2D, NOTCH2, TRAF3, CCND1, ARID1A, CREBBP, and TP53 were observed, with TRAF3 mutations standing out for their significant association with prolonged progression-free survival and overall survival in B-cell lymphomas. In contrast, mutations in PIK3CD and CREBBP were associated with inferior outcomes in T-cell lymphomas, highlighting the immunophenotype-specific impact of genetic alterations on treatment responses. These findings support the integration of comprehensive genomic profiling in planning treatment strategies and optimizing clinical outcomes in canine lymphomas.
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Search related cases āOriginal publication on Semantic Scholar: https://www.semanticscholar.org/paper/40506464