Peer-reviewed veterinary case report
Immune-Mediated Low Platelets in Dogs and Recent Vaccination
By Huang, A A et al.·Published in Journal of veterinary internal medicine·2012·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Idiopathic immune-mediated thrombocytopenia and recent vaccination in dogs.
- Species:
- dog
Plain-English summary
A 7-year-old mixed breed dog was diagnosed with immune-mediated thrombocytopenia (ITP), a condition where the immune system attacks the platelets, leading to bleeding problems. The study looked at whether recent vaccinations could be linked to this condition in dogs. Out of 48 dogs with ITP, only 8% had been vaccinated within 42 days of their diagnosis, compared to 14% of a control group. The researchers found no significant difference, suggesting that recent vaccinations are not a common cause of ITP in dogs, but further research is needed to be sure.
People also search for: dog ITP symptoms · immune-mediated thrombocytopenia in dogs · dog vaccination side effects
Abstract
BACKGROUND: Vaccination is often cited as a potential cause of immune-mediated thrombocytopenia (ITP) in dogs. Although an association has been documented in humans, particularly in children, this relationship has not been definitively established in dogs. OBJECTIVES: To identify the presence of an association between recent vaccination and ITP in dogs. ANIMALS: Forty-eight client-owned dogs with presumptive idiopathic ITP and 96 age-matched, client-owned dogs with non-immune-mediated disease. METHODS: Retrospective, case-control study. Dogs were identified through the Veterinary Medical Database (VMDB) and Hospital Information System at Purdue University. RESULTS: The median age at presentation for dogs with ITP was 7 years (range: 2-15 years). The majority of the ITP group was comprised of mixed breed dogs (38%); no pure breed was represented by more than 3 cases. The number of dogs that were vaccinated within 42 days of diagnosis of ITP did not differ significantly (P = .361) between cases of presumptive ITP (4/48, 8%) and the control group (13/96, 14%). CONCLUSIONS AND CLINICAL IMPORTANCE: This study failed to confirm the presence of an association between presumptive idiopathic ITP in dogs and recent vaccination; however, the possibility of an association cannot be completely ruled out based on the small sample populations and requires further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22151468/