Peer-reviewed veterinary case report
Immune cells in the small intestine of cats with inflammatory bowel
By Waly, Nashwa E et al.·Published in Journal of veterinary internal medicine·2004·School of Clinical Veterinary Science, United Kingdom·View original on PubMed →
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Original publication title: Immune cell populations in the duodenal mucosa of cats with inflammatory bowel disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic vomiting and diarrhea were studied to understand their immune system's response to inflammatory bowel disease (IBD). The researchers found that certain immune cells were more active in the intestines of cats with IBD compared to healthy cats, indicating a possible immune imbalance. While the overall number of some immune cells didn't differ significantly, specific markers showed increased activity in the affected cats. This suggests that IBD in cats may involve subtle changes in their immune response. Treatment options for IBD often include dietary changes and medications to manage symptoms.
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Abstract
The aim of this study was to characterize the phenotype of leukocytes infiltrating the duodenal mucosa of cats with inflammatory bowel disease (IBD) by using immunohistochemistry and computer-aided morphometry to assess whether immunologic markers would aid in characterization of IBD. Frozen and formalin-fixed duodenal biopsies were collected from cats referred for investigation of chronic vomiting, diarrhea, or both (n = 34). Reference ranges were previously established by using duodenal samples from healthy cats (n = 16). No significant difference was found in the number of immunoglobulin G+ (IgG+) or IgA+ in either the villous lamina propria or the crypt lamina propria between cats with IBD and control cats. T cells (CD3+) increased in number from crypt to the tip of the villi in biopsies from both diseased (mean +/- SD for each group was 18.8 +/- 6.6 and 17.7 +/- 4.2 cells/ 10,000 m2 in cryptal areas to 25.2 +/- 9.5 and 29.1 +/- 13.3 cells/10,000m2 in villous areas) and healthy animals (17.9 +/- 3.9 cells/10,000 microm2 in cryptal areas to 24.1 +/- 9.3 cells/10,000 microm2 in villous areas) and no significant difference was found between diseased and control cats. By contrast, major histocompatibility complex (MHC) class II expression by leukocytes with dendritic cell or macrophage morphology in the lamina propria was significantly greater in cats with IBD (13.3 +/- 4.2 cells/10,000 microm2 in cryptal area; P = .016) than in healthy cats (11.9 +/- 3.0 cells/10,000 microm2) and MHC class II expression by enterocytes also was more pronounced in these cats showing an overall intensity of expression of 7.1 +/- 4.0 cells/10,000 microm2 in cats with IBD as opposed to 0.0 +/- 0.0 cells/10,000 microm2 to 0.3 +/- 0.7 cells/10,000 microm2 in healthy cats. These findings suggest that a subtle immunologic dysregulation occurs in spontaneously arising feline IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15638264/