Peer-reviewed veterinary case report
Immune-mediated low neutrophils in 2 dogs explained
By McManus, P M et al.·Published in Journal of veterinary internal medicine·1999·Department of Pathobiology, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Immune-mediated neutropenia in 2 dogs.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog and a 7-year-old Labrador were both brought in for low white blood cell counts, which can lead to serious infections. The dogs were diagnosed with immune-mediated neutropenia, a condition where the immune system mistakenly attacks the body's own neutrophils, a type of white blood cell. Treatment involved medications to suppress the immune response, and both dogs showed improvement with their neutrophil counts rising back to normal levels.
People also search for: dog low white blood cell count · immune-mediated neutropenia treatment · why is my dog getting sick often
Abstract
Immune‐mediated neutropenia, also termed autoimmune neutropenia (AIN), is an uncommon event, rarely documented within veterinary literature, although the clinical profile and probable pathogenesis have been outlined in detail within medical literature. In this paper, we review 2 different manifestations of this disorder. The 1st case primarily involved peripheral destruction of mature neutrophils, with little impact on marrow precursors, whereas the 2nd case resulted in suppression of neutrophilic granulopoiesis within marrow. In both cases, absolute neutrophil counts dropped below 200/mL.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10449230/