Peer-reviewed veterinary case report
Dog developed joint pain and eye inflammation after zonisamide
By Baya, Paula et al.·Published in Veterinary medicine and science·2024·Department of Emergency and Critical Care, United States·View original on PubMed →
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Original publication title: Immune-mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy.
- Species:
- dog
Plain-English summary
A 7-year-old male neutered Siberian Husky with a history of seizures was brought in for cluster seizures after starting a new medication called zonisamide. Shortly after beginning this treatment, he developed joint swelling and eye inflammation, which are signs of immune-mediated polyarthritis (IMPA) and anterior uveitis. The veterinarian suspected these issues were caused by the zonisamide, so they stopped the medication. Fortunately, the dog's symptoms improved and resolved within a few weeks after discontinuing the drug.
People also search for: dog seizures treatment · Siberian Husky eye problems · zonisamide side effects in dogs
Abstract
The objective of this article is to describe a case of suspected zonisamide-induced immune-mediated polyarthritis (IMPA) and anterior uveitis in a dog. A 7-year-old male neutered Siberian Husky with a history of refractory idiopathic epilepsy was presented for cluster seizures. Following the addition of zonisamide to the antiepileptic regime, the dog developed new IMPA and anterior uveitis. Within a few weeks of discontinuation of the zonisamide, the dog's IMPA and anterior uveitis resolved. These immune-mediated conditions were thus presumed to be an idiosyncratic reaction to zonisamide. To our knowledge, this is the first report of IMPA and anterior uveitis in dogs associated with zonisamide administration at its recommended dose.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38403976/