Peer-reviewed veterinary case report
Dog with immune skin lesions after long steroid treatment for anemia
By Hasegawa, T et al.·Published in Nihon juigaku zasshi. The Japanese journal of veterinary science·1990·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Immune mediated skin lesions in a dog with autoimmune hemolytic anemia.
- Species:
- dog
Plain-English summary
A dog with autoimmune hemolytic anemia developed skin lesions after 18 months of treatment with prednisolone, a common steroid medication. The dog's skin and oral tissue were examined, revealing specific changes that indicated an immune response affecting the skin. Tests showed the presence of certain antibodies that suggested the dog's immune system was mistakenly attacking its own skin cells. This case highlights the complexities of autoimmune diseases in dogs, where treatment may need to be adjusted based on new symptoms like skin problems.
People also search for: dog skin lesions after medication · autoimmune hemolytic anemia in dogs · treatment for dog skin problems
Abstract
A canine case of Coombs' test positive and antinuclear antibody-negative hemolytic anemia was examined because of the development of skin lesions after 18 months treatment with prednisolone. Histopathological examination of biopsy specimens obtained from skin and oral mucosa revealed the acantholysis, edematous lesions of the stratum basale and mononuclear cell accumulation in the dermis. Deposits of immunoglobulin G and complement factor 3 were detected at the intercellular and dermoepidermal junction by the direct immunofluorescent test. From these results, the case was considered to be an autoimmune disease caused by distinct antibodies against different organs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2280484/