Peer-reviewed veterinary case report
Immune proteins linked to types of anemia in dogs
By Lucidi, Cynthia A et al.·Published in Journal of veterinary internal medicine·2021·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Immunoglobulin G and phosphatidylserine in regenerative and nonregenerative immune-mediated anemias of dogs.
- Species:
- dog
Plain-English summary
A group of dogs with immune-mediated anemia, a condition where the immune system attacks their own red blood cells, was studied to understand the role of certain proteins in this process. Researchers found that dogs with this type of anemia had higher levels of specific proteins (Immunoglobulin G and phosphatidylserine) that could lead to the destruction of their red blood cells. This suggests that these proteins might be involved in the disease's progression. Understanding these factors could help veterinarians develop better treatments for affected dogs.
People also search for: dog immune-mediated anemia treatment · why is my dog anemic · dog red blood cell destruction causes
Abstract
BACKGROUND: Although precursor-targeted immune-mediated anemia (PIMA) is thought to be caused by immune targeting of erythroid precursors (nucleated RBCs, nRBCs), its pathogenesis is unknown. Immunoglobulin G (IgG) or phosphatidylserine (PS) may promote nRBC destruction in PIMA. HYPOTHESIS: Dogs with PIMA have increased nRBC IgG and PS, and dogs with immune-mediated hemolytic anemia (IMHA) have increased RBC PS compared to healthy dogs. ANIMALS: Blood from 20 healthy dogs and from dogs with IMHA (11) or other (non-IMHA) conditions (9), and marrow aspirates with or without blood from 10 healthy dogs and from dogs with PIMA (17) or other (non-IMHA, non-PIMA) conditions (7). METHODS: Marrow nRBC stages were separated by density gradient. Flow cytometry was used to assess the percentage of RBCs or nRBCs with increased IgG or PS. RESULTS: Red blood cell (RBC) IgG positivity was increased in 9/11 IMHA dogs and 0/9 non-IMHA dogs. Red blood cell PS positivity was increased in 10/11 IMHA dogs and 2/9 non-IMHA dogs. Five of 17 PIMA dogs had increased nRBC IgG positivity in mid- or late-stage fractions, whereas all 7 non-PIMA dogs were negative. Mid- and late-stage erythroid precursor PS was significantly higher in PIMA dogs compared to healthy dogs. Five of 14 PIMA dogs had increased RBC IgG positivity. CONCLUSIONS: Immunoglobulin G and PS may promote destruction of nRBCs in PIMA dogs; PS may promote destruction of RBCs in IMHA dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34716708/