Peer-reviewed veterinary case report
Blood and immune changes in dogs with visceral leishmaniasis
By José Nivaldo da Silva et al.·Published in Revista Brasileira de Parasitologia Veterinária·2018·View original on DOAJ →
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Original publication title: Immunohaematological and rheological parameters in canine visceral leishmaniasis
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with canine visceral leishmaniasis (a serious disease caused by a parasite) showed changes in their blood that could help monitor their condition. The study found that these dogs had lower red blood cell counts and platelets compared to healthy dogs, but higher levels of certain proteins and antibodies. The blood flow in the infected dogs was different, indicating potential issues with circulation. These findings suggest that simple blood tests could be useful for tracking the health of dogs with this disease.
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Abstract
Abstract The aim of this study was to find correlations between haematological and rheological parameters in canine visceral leishmaniasis (CLV). Enrolled dogs with CVL (n=31) had a confirmed diagnosis using the rapid test Dual Path Platform (TR DPP®) kit and Polymerase Chain Reaction (PCR) assay. A control group (n=31) comprised healthy dogs with negative results for the TR DPP® kit and PCR assay. Haematological parameters and total protein, albumin, globulin, and antibody were assessed. The rheological properties of the blood samples were also determined. Erythrocytes, haematocrit and platelet values of dogs in the CVL group were found to be lower than those of the control group. The total protein, globulin and IgG concentrations were higher in serum samples from the CVL group. The blood flow curve demonstrated increased shear rates in the CVL group. The viscosity of the blood from the infected animals was lower than in the healthy dogs. A positive correlation was found between erythrocyte numbers and blood viscosity. These data suggest that changes in the flow curve and viscosity of blood as well as the erythrocyte values may be a viable low-cost alternative for the monitoring of dogs with visceral leishmaniasis.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1590/s1984-296120180021