Peer-reviewed veterinary case report
How immune cells help canine skin histiocytoma tumors shrink
By Pires, Isabel et al.·Published in In vivo (Athens, Greece)·2013·Department of Veterinary Sciences. University of Trá·View original on PubMed →
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Original publication title: Immunohistochemical and immunoelectron study of major histocompatibility complex class-II antigen in canine cutaneous histiocytoma: its relation to tumor regression.
- Species:
- dog
Plain-English summary
A study looked at skin tumors called cutaneous histiocytomas in dogs to understand how their immune system helps these tumors shrink. Researchers found that all tumors showed specific markers (MHC class-II) that indicated immune activity, especially in cases where the tumors were regressing. They noticed that as the tumors shrank, there was an increase in certain immune cells (T- and B-lymphocytes) and a change in how the tumor cells displayed these markers. This suggests that the immune response plays a key role in helping these tumors to regress.
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Abstract
In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major histocompatibility complex (MHC) class-II immuno-expression and the number of T- and B-lymphocytes and macrophages were analyzed in 93 cases of CCH. MHC class-II was also studied in 16 cases of CCH by immunoelectron microscopy. All tumors expressed MHC class-II, and two major staining patterns were identified: focal juxtanuclear cytoplasmic staining and rim-like staining along the cell periphery. The MHC class-II labelling pattern and T- and B-lymphocyte infiltrates were associated with tumor regression. In regressing lesions, MHC class-II molecules shift to the cell surface and an increase of both T- and B-lymphocytes were noted. The increasing expression of MHC class-II molecules on the cell surface could be a significant factor for the onset and progression of tumour regression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23422487/