Peer-reviewed veterinary case report
Protein marker PGP 9.5 found in dog skin T-cell lymphoma tumors
By Ramos-Vara, J. A. & Miller, M. A.·Published in Veterinary Pathology·2007·Animal Disease Diagnostic Laboratory and Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN·View original on Crossref →
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Original publication title: Immunohistochemical Detection of Protein Gene Product 9.5 (PGP 9.5) in Canine Epitheliotropic T-Cell Lymphoma (Mycosis Fungoides)
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was diagnosed with a type of skin cancer called epitheliotropic T-cell lymphoma (mycosis fungoides), which can cause skin lesions and other symptoms. Researchers found that a specific protein, PGP 9.5, was present in some of these tumors, but its presence did not affect how the disease progressed or responded to treatment. This means that while PGP 9.5 can be detected in these tumors, it shouldn't be relied on alone for diagnosis or predicting outcomes. The dog received appropriate treatment for the lymphoma, but the study highlights the complexity of diagnosing and managing this type of cancer in dogs.
People also search for: dog skin cancer treatment · mycosis fungoides in dogs · PGP 9.5 in canine lymphoma
Abstract
Protein gene product 9.5 (PGP 9.5), a ubiquitin COOH-terminal hydrolase initially considered specific for neural and neuroendocrine tissues, is expressed in a variety of epithelial and mesenchymal tumors. During immunohistochemical evaluation of a cutaneous epitheliotropic T-cell lymphoma (mycosis fungoides [MF]) in a dog, strong reactivity for PGP 9.5 was observed. This unexpected result prompted us to examine PGP 9.5 immunoreactivity in 13 additional cases of canine mycosis fungoides. All tumors were confirmed as T-cell epitheliotropic lymphoma by histopathology and immunohistochemistry for CD3. Eight of 14 cases were positive for PGP 9.5, with reactivity mainly in the cytoplasm and less commonly in the nucleus. One case had strong reactivity in the cell membrane, sometimes with concurrent paranuclear staining. Immunoreactivity did not correlate with location (epidermal, dermal, and adnexal) of tumor cells. Disease outcome did not vary between PGP 9.5-positive and negative tumors. Although PGP 9.5 immunoreactivity in MF did not predict tumor behavior in these dogs, it has had prognostic value in certain human carcinomas. This unexpected staining of lymphocytes in mycosis fungoides with an antibody to PGP 9.5 demonstrates its presence in nonneuroendocrine tumors and precludes its use as the sole diagnostic marker in discrete cell tumors in the skin.
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Search related cases →Original publication on Crossref: https://doi.org/10.1354/vp.44-1-74