Peer-reviewed veterinary case report
Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2010
- Authors:
- Amorim, R L et al.
- Affiliation:
- School of Veterinary Medicine and Animal Science · Brazil
- Species:
- dog
Abstract
Vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) appear to play a critical role in tumour neovascularization. In this study, we have investigated the expression of VEGF and PGE-2 in 53 canine cutaneous mast cell tumours (MCTs). Immunohistochemistry of tissue sections revealed that VEGF and PGE-2 were expressed in all mast cell tumours studied. When the expression patterns of VEGF and PGE-2 were compared with tumour grade according to Patnaik criteria, the only significant correlation observed was between PGE-2 staining intensity and tumour pathological grade, with grade II and III tumours having higher PGE-2 staining, both in intensity and percentage of cells stained, than grade I tumours (P < 0.05).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20230578/