Peer-reviewed veterinary case report
MCAM/CD146 protein found in 66% of dog melanomas
By Abou Asa, S·Published in Journal of comparative pathology·2017·Faculty of Applied Biological Sciences, Japan·View original on PubMed →
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Original publication title: Immunohistochemical Expression of MCAM/CD146 in Canine Melanoma.
- Species:
- dog
Plain-English summary
A study looked at melanoma, a common type of cancer in dogs, particularly in the mouth, skin, and eyes. Researchers found that a specific protein called MCAM/CD146 was present in many of the melanoma samples they examined, especially in oral tumors. This suggests that targeting this protein could be a potential treatment option for dogs with oral melanoma. If your dog has been diagnosed with melanoma, discussing treatment options that focus on this protein with your veterinarian may be beneficial.
People also search for: dog melanoma treatment · oral melanoma in dogs · MCAM/CD146 in canine cancer
Abstract
MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and promotes tumour growth, angiogenesis and metastasis. Melanoma is the most common malignant oral tumour of dogs and also arises in the skin, nail bed and footpad. The aim of this study was to investigate the immunohistochemical expression of MCAM/CD146 in 51 canine melanomas, including oral, cutaneous and ocular tumours. Seventeen of the 51 (33.3%) cases were negative, eight (15.7%) were weakly positive, seven (13.7%) were moderately positive and 19 (37.3%) were strongly positive. MCAM/CD146 was expressed by both oral and cutaneous melanomas; however, the intensity and the extent of the immunoreactivity was higher in oral (P = 0.009) than in cutaneous tumours (P = 0.058). Most ocular melanomas did not express MCAM/CD146 (P = 0.256). Expression of MCAM/CD146 by canine melanomas may suggest the molecule as a target for treatment, especially in oral melanomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28735667/