Peer-reviewed veterinary case report
How vimentin, E-cadherin, and CD45 help diagnose dog skin tumors
By S. S. Oda et al.·Published in Brazilian Journal of Biology·2024·View original on DOAJ →
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Original publication title: Immunohistochemical expression of vimentin, E-cadherin, and CD45 in natural cases of canine cutaneous round tumors
- Species:
- dog
Plain-English summary
A group of dogs with skin tumors was studied to understand the types and characteristics of these round cell tumors. The most common tumor found was a transmissible venereal tumor, affecting 48 out of 64 dogs, while others included histiocytomas and histiocytic sarcomas. The researchers used special tests to help identify these tumors, finding that certain markers were present in the tumor cells. This information can help veterinarians make accurate diagnoses and determine the best treatment options for dogs with these types of skin tumors.
People also search for: dog skin tumor types · transmissible venereal tumor in dogs · histiocytoma treatment for dogs
Abstract
Abstract Round cell tumors are common cutaneous lesions in dogs, with increased occurrence percentages among different skin tumors. This study aimed to investigate the frequency as well as gross and pathological characteristics of round cell tumors in natural cases of tumorous dogs in relation to breed, sex, and age. Moreover, it aimed to evaluate the immunohistochemical expression of a panel of immunohistochemical stains, including vimentin, E-cadherin, and cluster of differentiation (CD45) as an adjunct technique for the differential diagnosis of cutaneous round cell neoplasm. Data were collected from 64 dogs of both sexes (36 females and 28 males), various breeds, and different ages (8 months to 7 years). The histopathological nature of neoplastic growth was reported, and neoplasm prevalence was classified using age, sex, breed, and site on the body. We observed 48 cases of transmissible venereal tumors, 12 cutaneous histiocytomas, and 4 histiocytic sarcoma. Immunohistochemical characterization revealed an intense positive immunoreactivity for vimentin in transmissible venereal tumor cells and moderate positive immunoreactivity for E-cadherin and CD45 in cutaneous histiocytoma and histiocytic sarcoma cells. In conclusion, the canine transmissible venereal tumor was the most frequent form of round cell tumor; thus, a definitive cutaneous neoplasm diagnosis should be based on histopathological morphology and immunohistochemical findings.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1590/1519-6984.278769