Peer-reviewed veterinary case report
Side effects of vagus nerve stimulators in dogs with epilepsy
By Harcourt-Brown, Thomas R & Carter, Michael·Published in Journal of veterinary internal medicine·2021·University of Bristol School of Veterinary Sciences, United Kingdom·View original on PubMed →
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Original publication title: Implantable vagus nerve stimulator settings and short-term adverse effects in epileptic dogs.
- Species:
- dog
Plain-English summary
A group of 16 dogs with idiopathic epilepsy received an implantable vagus nerve stimulator to help control their seizures. While most dogs tolerated the treatment well, coughing was a common side effect, especially in those who had their stimulation increased rapidly. Dogs that had their stimulation increased slowly experienced fewer issues and were able to reach the desired stimulation level without intolerable coughing. Overall, the treatment showed promise, with most dogs managing the side effects effectively and continuing their therapy.
People also search for: dog epilepsy treatment · vagus nerve stimulator for dogs · why is my dog coughing after surgery
Abstract
BACKGROUND: Implantable vagus nerve stimulation (VNS) devices can be used to treat epilepsy in dogs. Adverse effects and short-term complications associated with delivering suggested therapeutic electrical stimulation (>1.5 mA) are not well-described. OBJECTIVES: To compare complications and adverse effects observed with standard and rapid protocols of current increase. ANIMALS: Sixteen client-owned dogs with idiopathic epilepsy. METHODS: Nonrandomized, nonblinded prospective cohort study. Surgical complications, stimulation-related adverse effects, modifications to stimulator settings, number of hospital visits, and time to reach 1.5 mA stimulation current without intolerable adverse effects were described in dogs receiving current increases every 1 to 3 weeks (slow ramping) and dogs receiving current increases every 8 to 12 hours (fast ramping). RESULTS: Self-resolving surgery site seromas formed in 6 dogs. No other surgical complications were observed. Fourteen dogs reached 1.5 mA. Coughing (11/14 dogs; 5 slow, 6 fast ramping) was the most common adverse effect. Intolerable coughing that limited current increases despite changing other stimulus parameters occurred in 6/7 of the fast-ramping group and in none of the slow-ramping group. Median time to 1.5 mA was 72 days (range, 28-98) in the slow-ramping group and 77 days (range, 3-152) in the fast-ramping group. Median number of clinic visits was 6 for the slow-ramping group (range, 5-6) and 3 for the fast-ramping group (range, 1-7). CONCLUSIONS AND CLINICAL IMPORTANCE: Coughing is a common adverse effect of VNS in dogs and generally is well tolerated, particularly if current is increased slowly and other stimulation parameters are adapted for effect.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34472639/