Importância da barreira epidérmica na dermatite atópica canina: Revisão

Abstract

Canine Atopic Dermatitis (CAD) is an allergic, chronic and inflammatory skin disease which affects 10-15% of canine population. For several years, pathogenesis of the disease had been linked to hypersensitivity processes mediated by IgE, but during the last decade, researchers have led their efforts to demonstrate the importance of the skin barrier in the development of CAD, based most of the times on previous studies related with Human Atopic Dermatitis. Studies in dog sincluding transepidermal water loss, skin moisture levels and abnormalities in the stratum corneum lipids and in the superficial proteins of the epidermis, filaggrin mainly, have been very important to advance the understanding of this common and frequent disease in veterinary medicine.