Peer-reviewed veterinary case report
Feline kidney lymphoma cases, treatment, and survival study
By Williams, Ashlyn G et al.·Published in Journal of feline medicine and surgery·2021·The Cancer Institute, United States·View original on PubMed →
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Original publication title: Incidence and treatment of feline renal lymphoma: 27 cases.
- Species:
- cat
Plain-English summary
A group of 27 cats with kidney cancer (renal lymphoma) was studied to understand how to treat this condition better. The cats showed various symptoms, but the most common treatment options included corticosteroids or a more intensive chemotherapy regimen called L-CHOP. Cats that received L-CHOP lived significantly longer, with a median survival of about 203 days compared to just 50 days for those on corticosteroids alone. This research highlights the importance of chemotherapy for improving survival in cats with renal lymphoma.
People also search for: cat kidney cancer treatment · feline lymphoma symptoms · renal lymphoma survival rate · cat chemotherapy options · what is renal lymphoma in cats
Abstract
OBJECTIVES: Lymphoma is the most common feline hematopoietic malignancy. Incidence of renal lymphoma has not been reported as a subset of a large population of feline lymphoma cases. Previous studies have reported renal lymphoma as both a singular entity as well as a component of multicentric disease. The clinical presentation, diagnostic evaluation, therapy and outcomes related to renal lymphoma have not been reported since Mooney et al in 1987. This retrospective study aimed to describe the incidence of renal lymphoma, clinical signs, treatment and survival. METHODS: Using a database of cats diagnosed with lymphoma between January 2008 and October 2017, cats with renal lymphoma were selected for further analysis. Cases were retrospectively staged according to Mooney et al (1987) and Gabor et al (1998). Data collected included age, clinical signs, clinicopathologic data, diagnostic imaging findings, lymphoma diagnostic method(s), treatment protocol(s) and survival time. Analyses comparing median survival based on therapy administered, renal lymphoma vs multicentric lymphoma, central nervous system involvement, presence of azotemia, anemia and International Renal Interest Society (IRIS) stage at diagnosis were performed. RESULTS: From a population of 740 cats with lymphoma, 27 cats had renal lymphoma (incidence, 3.6%), and 14 of those cats had multicentric lymphoma. Fewer stage IV and V cases were identified in this data set compared with Mooney et al; however, not all cats were completely staged. Median survival (range) for cats receiving corticosteroids alone compared with those receiving an L-CHOP (L-asparaginase, vincristine, cyclophosphamide, doxorubicin, prednisolone)-based protocol was 50 days (20-1027 days) in the corticosteroid group and 203 days (44-2364 days) for the L-CHOP group ( = 0.753) for cats that died secondary to lymphoma. CONCLUSIONS AND RELEVANCE: Neither clinical stage nor other factors were predictive of survival. Prospective studies are required to determine the optimal chemotherapy protocol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33464143/