Peer-reviewed veterinary case report
Higher AST/ALT ratio linked to kidney injury in dogs with Babesia
By Zygner, W et al.·Published in Polish journal of veterinary sciences·2012·Department of Preclinical Sciences·View original on PubMed →
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Original publication title: Increased AST/ALT ratio in azotaemic dogs infected with Babesia canis.
- Species:
- dog
Plain-English summary
A group of dogs infected with Babesia canis were found to have higher levels of liver enzymes, specifically a higher AST/ALT ratio, which can indicate liver or kidney issues. Among these dogs, some were also experiencing kidney problems (azotaemia) and anemia. The study showed that dogs with kidney issues had a significantly higher AST/ALT ratio compared to those without. This suggests that kidney injury may be affecting liver function in these dogs. If your dog shows signs of illness, it's important to consult your veterinarian for proper testing and treatment.
People also search for: dog Babesia canis infection · dog kidney problems symptoms · elevated liver enzymes in dogs
Abstract
The AST/ALT ratio was estimated in 182 dogs infected with Babesia canis. Among these dogs 65 had anaemia and 68 were azotaemic. Student's t test was used to compare means of the AST/ALT ratio in anaemic and non-anaemic dogs, and in azotaemic and non-azotaemic dogs (p < 0.05). The differences in AST/ALT ratio between anaemic (1.52 +/- 1.15) and non-anaemic (1.76 +/- 1.34) dogs were statistically insignificant (p = 0.23), however, the comparison of AST/ALT ratio between azotaemic (2.68 +/- 1.52) and non-azotaemic (1.08 +/- 0.53) dogs revealed a significantly higher value of this index in azotaemic dogs (p = 0.00). The present results suggest that kidney injury contributed to increased AST activity in these dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23214368/