Peer-reviewed veterinary case report
Increased kidney BMP-7 protein in dogs with congenital portosystemic
By van Dongen, Astrid M et al.·Published in Veterinary journal (London, England : 1997)·2015·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt.
- Species:
- dog
Plain-English summary
A group of dogs with a congenital portosystemic shunt (CPSS), a condition where blood bypasses the liver, often showed enlarged kidneys. Researchers found that a growth factor called bone morphogenetic protein 7 (BMP-7) was more active in the kidneys of these dogs compared to healthy dogs. This increased BMP-7 signaling might help explain some of the kidney problems seen in dogs with CPSS. Understanding this could lead to better treatments for kidney issues related to this condition.
People also search for: dog kidney problems CPSS · congenital portosystemic shunt in dogs · BMP-7 kidney treatment for dogs
Abstract
Dogs with a congenital portosystemic shunt (CPSS) often have enlarged and hyper-filtrating kidneys. Although expression of different growth factors has been well-described in the livers of dogs affected with a CPSS, their expression in the kidneys has yet to be determined. Bone morphogenetic protein 7 (BMP-7), hepatocyte growth factor (HGF) and transforming growth factor (TGF)-β have been implicated in renal development (BMP-7, HGF) or the onset of renal fibrosis (TGF-β). Moreover, BMP-7 and HGF have protective properties in renal fibrosis. In this study, the expression and activity of BMP-7 were investigated in renal biopsies obtained from 13 dogs affected with a CPSS and compared to similar samples from age-matched healthy control dogs. Both quantitative reverse-transcriptase PCR and Western blotting showed up-regulated BMP-7 signalling in kidneys of CPPS-affected dogs. These research findings may help to explain the renal pathology/dysfunction in dogs affected with a CPSS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25920772/