Peer-reviewed veterinary case report
High monocyte levels and MCP-1 link to worse lymphoma outlook in dogs
By Perry, J A et al.·Published in Veterinary and comparative oncology·2011·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Increased monocyte chemotactic protein-1 concentration and monocyte count independently associate with a poor prognosis in dogs with lymphoma.
- Species:
- dog
Plain-English summary
A group of 26 dogs diagnosed with lymphoma showed that higher levels of certain immune cells and a specific protein (monocyte chemotactic protein-1 or MCP-1) were linked to a worse outcome after treatment. These dogs had increased counts of monocytes and neutrophils, which are types of white blood cells, and higher MCP-1 levels compared to healthy dogs. The dogs received chemotherapy, and those with elevated levels of these cells and proteins had a shorter time without disease. This suggests that checking these levels before treatment could help predict how well a dog with lymphoma might do.
People also search for: dog lymphoma prognosis · elevated white blood cells in dogs · chemotherapy for dog lymphoma
Abstract
Overexpression of the chemokine monocyte chemotactic protein-1 (MCP-1) has been associated with a poor prognosis in many human cancers. Increased MCP-1 concentrations may promote tumour progression by increasing mobilization of myeloid derived suppressor cells such as immature monocytes and neutrophils. We hypothesized that increased numbers of peripheral neutrophils or monocytes and increased MCP-1 concentrations would predict a worse outcome in dogs with multicentric lymphoma. In this retrospective study involving 26 client-owned dogs diagnosed with lymphoma, we show that peripheral neutrophil and monocyte counts as well as serum MCP-1 concentrations were significantly elevated relative to healthy control animals, and that such increases were associated with a decreased disease-free interval in dogs treated with chemotherapy based on cyclophosphamide, vincristine, doxorubicin and prednisone (CHOP). To our knowledge, this is the first study showing that pretreatment evaluation of monocyte and neutrophil counts can provide important prognostic information in dogs with lymphoma. The mechanisms underlying these observations remain to be determined.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21303454/