Peer-reviewed veterinary case report
More tissue factor protein in platelets of dogs with immune anemia
By Hennink, Imke et al.·Published in Veterinary immunology and immunopathology·2018·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Increased number of tissue factor protein expressing thrombocytes in canine idiopathic immune mediated hemolytic anemia.
- Species:
- dog
Plain-English summary
A dog diagnosed with idiopathic immune-mediated hemolytic anemia (cIIMHA) is at a high risk of serious complications, especially within the first two weeks. This condition can lead to dangerous blood clots or organ failure due to an increased number of certain proteins in the dog's blood cells. Research shows that dogs with cIIMHA have more of these proteins in their blood platelets compared to healthy dogs, which may explain their heightened risk of complications. Monitoring and treatment during this critical period are essential to manage the condition and reduce risks.
People also search for: dog immune-mediated hemolytic anemia treatment · why is my dog bleeding · cIIMHA symptoms in dogs
Abstract
Dogs suffering from canine idiopathic immune mediated hemolytic anemia (cIIMHA) are at great risk of dying particularly in the first two weeks after the diagnosis is made. This high mortality risk may be associated with the development of thromboembolism (TE) and/or disseminated intravascular coagulation (DIC) resulting in organ failure. The exact mechanism of the development of TE and/or DIC in cIIMHA is still undetermined. Therefore, this study investigates the presence of tissue factor (TF) in thrombocytes of dogs suffering from cIIMHA, using OptiPrep™ for the isolation of blood cells and immunocytochemistry (ICC) to visualize TF on thrombocytes. The normalised TF quantity, acquired with 'colour deconvolution' (ImageJ plug in), revealed that in cIIMHA dogs the fraction TF positive thrombocytes was statistically significant higher (P < 0.001; mean 0.79; n = 7) compared to the fraction TF positive thrombocytes of the healthy dogs (mean 0.43; n = 9). We further have indications that the fraction of TF positive thrombocytes decreases with time and therapy, but that the progression rate differs individually. Since cIIMHA dogs have more thrombocytes that are TF-positive compared to healthy dogs, this may explain the increased risk to develop TE and DIC. Furthermore, it seems that the number of TF-positive thrombocytes in cIIMHA dogs remains high during the first two weeks of the disease, the time when the animals are at greatest health risk.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29695321/