Peer-reviewed veterinary case report
Immune response triggered by dendritic cell vaccine for canine
By Tamura, Kyoichi et al.·Published in Veterinary journal (London, England : 1997)·2008·Department of Veterinary Clinical Pathology, Japan·View original on PubMed →
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Original publication title: Induction of dendritic cell-mediated immune responses against canine malignant melanoma cells.
- Species:
- dog
Plain-English summary
A group of dogs with malignant melanoma was vaccinated using their own immune cells mixed with melanoma cell proteins to see if it would help their bodies fight the cancer. The dogs showed a strong immune response, indicating that this treatment could effectively stimulate their immune systems to target the melanoma cells. This approach suggests a promising new way to treat dogs with this type of cancer, potentially improving their chances of recovery.
People also search for: dog melanoma treatment · canine cancer vaccine · immune response in dogs with melanoma
Abstract
To establish the basis for the use of dendritic cells (DC) in the treatment of canine melanoma, dogs were vaccinated using autologous DC pulsed with canine melanoma CMM2 cell lysate in the presence of keyhole limpet haemocyanin (KLH) in vitro (CMM2-KLH-DC), and the induction of immune responses against CMM2 cells in vivo was examined using the delayed-type hypersensitivity (DTH) skin test. The DTH responses against CMM2 cells and KLH were observed in dogs vaccinated with CMM2-KLH-DC, while the responses against KLH but not CMM2 cells were detected with DC pulsed with KLH alone (KLH-DC). Recruitment of CD8 and CD4 T cells was detected in the positively responding sites, suggested that vaccination with CMM2-KLH-DC efficiently elicits T cell-mediated immunity against CMM-2 cells in vivo. These findings demonstrate the potential utility of DC-based tumour vaccination in the treatment of canine malignant melanoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17208475/