Peer-reviewed veterinary case report
Does adding asparaginase improve chemo for dog lymphoma
By Jeffreys, Antonella Borgatti et al.·Published in Journal of the American Animal Hospital Association·2005·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Influence of asparaginase on a combination chemotherapy protocol for canine multicentric lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with multicentric lymphoma (a type of cancer affecting the lymph nodes) was treated with a combination of chemotherapy drugs, including a new drug called asparaginase. Researchers wanted to see if adding asparaginase would improve the treatment's effectiveness. After comparing the results of dogs receiving the standard chemotherapy and those getting asparaginase, they found that asparaginase did not significantly help in achieving remission or extending the time before the cancer progressed.
People also search for: dog lymphoma treatment · asparaginase for dogs · chemotherapy for canine cancer
Abstract
Combination chemotherapy is superior to single-agent chemotherapy for treating canine lymphoma, but the effect of each drug on efficacy remains unknown. By comparing 34 dogs treated with a modified cyclophosphamide, vincristine, prednisone (COP) chemotherapy protocol and 42 dogs given asparaginase in the induction phase of the same protocol, the effect of asparaginase on the chemotherapeutic protocol was determined. Both groups were compared based on clinical response at 2 weeks and 6 weeks, and on the progression-free interval. Asparaginase did not significantly increase the likelihood of a clinical remission or prolong the initial progression-free interval in the dogs studied.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15995158/