Peer-reviewed veterinary case report
Carboplatin infusion raises blood flow in dog bone cancer tumors
By DiResta, Gene R et al.·Published in Cancer chemotherapy and pharmacology·2008·Department of Surgery, United States·View original on PubMed →
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Original publication title: Influence of carboplatin infusion on osteosarcoma blood flow.
- Species:
- dog
Plain-English summary
A dog with osteosarcoma (a type of bone cancer) was treated with carboplatin, a chemotherapy drug, to see how it affected blood flow in the tumor. During the treatment, researchers found that blood flow in the tumor increased significantly, showing a quick response shortly after starting the infusion. This suggests that carboplatin may help improve circulation in the tumor area, which could be beneficial for treatment. The findings indicate that carboplatin has effects beyond just fighting cancer, potentially helping with blood flow as well.
People also search for: dog osteosarcoma treatment · carboplatin for dog cancer · how does chemotherapy affect blood flow in tumors
Abstract
PURPOSE: Herein we report that carboplatin infusion influenced tumor blood flow signal independent of the mechanical decompression induced by the artificial lymphatics system technology that was being evaluated as part of a randomized veterinary clinical trial, treating spontaneously occurring canine appendicular osteosarcoma, a tumor very similar to its human counterpart. METHODS: Blood flow within the central region of the tumor was recorded continuously using laser Doppler flowmetry, a real-time measurement technology. Time-averaged flow values were computed from segments taken from the recordings immediately before starting carboplatin infusion, and during infusion. RESULTS: Carboplatin increased the tumor blood flow signal by an additional 59 +/- 26% (mean +/- SEM; p = 0.06) over the increase induced by the decompression. The increase started within 49 +/- 46 s after the start of infusion, had a response time constant of 19 +/- 21 s and persisted throughout the infusion, ending shortly after infusion ended. CONCLUSION: The rapidity of the flow signal increase suggests that carboplatin may have an autonomic effect on circulation, either local or systemic. The observations identify a new action of this drug and suggest a possible mechanism to exploit therapeutically.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17932675/