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Peer-reviewed veterinary case report

Influence of phosphate-buffered sucrose solution on early graft function in feline renal autotransplantation.

Journal:
Research in veterinary science
Year:
2014
Authors:
Katayama, Masaaki et al.
Affiliation:
Iwate University · Japan
Species:
cat

Abstract

Graft perfusion with cold heparinized saline has known to induce ischemia and reperfusion injury in feline kidney transplantation. In this study, the effects of phosphate-buffered sucrose solution and heparinized saline solution on early kidney graft function were compared in feline kidney autotransplantation. Perfusion of grafts with or without hypothermic storage with chilled phosphate-buffered sucrose solution prevented ischemia and reperfusion injury despite a very short ischemic time. The results of our study suggest that phosphate-buffered sucrose perfusion and storage solution should be effective to reduce ischemia and reperfusion injury despite a very short ischemic time in feline kidney transplantation.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/25104321/