Peer-reviewed veterinary case report
Urine cystatin C test for kidney problems in dogs
By Monti, P et al.·Published in The Journal of small animal practice·2012·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Initial evaluation of canine urinary cystatin C as a marker of renal tubular function.
- Species:
- dog
Plain-English summary
A group of dogs with kidney disease was tested for a new urine marker called cystatin C to see if it could help identify renal problems. Researchers found that dogs with kidney disease had higher levels of cystatin C compared to healthy dogs and those with other health issues. This test is precise and can be easily done in regular veterinary labs. The findings suggest that measuring cystatin C in urine could be a useful tool for veterinarians to evaluate kidney function in dogs.
People also search for: dog kidney disease symptoms · urine test for dog kidney function · cystatin C test for dogs
Abstract
OBJECTIVES: To evaluate the performance of a particle-enhanced turbidimetric assay for measuring canine urinary cystatin C and to investigate if the urinary cystatin C to creatinine ratio is higher in dogs with renal disease than in non-renal disease dogs. METHODS: Urinary cystatin C was measured by particle-enhanced turbidimetric assay using an avian antihuman cystatin C antibody and the performance of this assay was evaluated. Clinical relevance was tested in 46 dogs that were divided into three groups: healthy dogs (n=14), non-renal disease dogs (n=17) and dogs with renal disease (n=15). RESULTS: The assay was linear (R(2)=0·99) and precise (mean intra- and inter-assay coefficients of variation were 2·3 and 2·9%, respectively). The recovery was 111·5% and the limit of blank was 0·02 mg/L. Urinary cystatin C and urinary cystatin C to creatinine ratio differed significantly (P<0·001) between the three cohorts of dogs. CLINICAL SIGNIFICANCE: Measurement of cystatin C by particle-enhanced turbidimetric assay performed with high precision and linearity. This assay can be processed on automated clinical chemistry analysers making it widely available to commercial laboratories. Urinary cystatin C to creatinine ratio can differentiate dogs with renal disease from dogs without renal disease. These preliminary results suggest that urinary cystatin C to creatinine ratio is a promising marker for evaluating renal tubular function.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22489749/