Peer-reviewed veterinary case report
Injection site-associated sarcoma in the cat: treatment recommendations and results to date.
- Journal:
- Journal of feline medicine and surgery
- Year:
- 2013
- Authors:
- Ladlow, Jane
- Affiliation:
- Department of Veterinary Medicine · United Kingdom
- Species:
- cat
Plain-English summary
Feline injection site-associated sarcomas (FISSs) are tumors that can develop in cats, often linked to vaccination sites, and have been a concern since the early 1990s. These tumors can be challenging to treat, as up to 25% of affected cats may have cancer that has spread to the lungs. The main treatment is usually aggressive surgery to remove the tumor, but even when the surgery is successful, there's a chance the tumor could come back in about one-third of cases. While additional treatments like radiation and chemotherapy are being explored, their effectiveness is still not fully understood. Overall, the review highlights the importance of surgical removal and provides insights into the survival times based on different treatment methods.
Abstract
PRACTICAL RELEVANCE: Feline injection site-associated sarcomas (FISSs) have been the cause of much controversy and concern since they were first reported in the early 1990s. While not solely associated with vaccination, there are implications for vaccination sites and schedules and, while guidance has been published, this appears to be permeating only slowly through to general practice. CLINICAL CHALLENGES: Up to one-quarter of cats with this difficult condition have metastatic lung involvement. The mainstay of treatment is aggressive surgery, but even in cases where full excision with clean margins is achieved, tumour recurrence is anticipated in about one-third of cases. The role of radiotherapy and chemotherapy as adjuvant treatments has yet to be clearly defined. PATIENT GROUP: FISSs are often seen in younger cats, with a peak presentation at 6-7 years and a second peak at 10-11 years. EVIDENCE BASE: This review summarises the diagnosis and management of FISS with reference to the latest published treatment results. It focuses on surgical excision but also covers adjuvant radiotherapy and chemotherapy, and gives median survival times for the different treatment approaches.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23603504/