Peer-reviewed veterinary case report
Insulin Therapy in Small Animals, Part 1: General Principles.
- Journal:
- The Veterinary clinics of North America. Small animal practice
- Year:
- 2023
- Authors:
- Fleeman, Linda & Gilor, Chen
- Affiliation:
- Animal Diabetes Australia · Australia
Plain-English summary
This research discusses how understanding insulin and diabetes can help improve treatment for pets with diabetes. It explains that there isn't one "best" type of insulin for all pets, as different formulations work differently. For example, some insulins need to be given twice a day and should have a consistent effect throughout the day. In dogs, only two types of insulin, glargine U300 and degludec, provide this steady action, while in cats, glargine U300 is the most reliable option. Overall, the findings suggest that choosing the right insulin formulation is important for effective diabetes management in pets.
Abstract
Understanding the pharmacology of insulin and how it relates to the pathophysiology of diabetes can lead to better clinical outcomes. No insulin formulation should be considered "best" by default. Insulin suspensions (NPH, NPH/regular mixes, lente, and PZI) as well as insulin glargine U100 and detemir are intermediate-acting formulations that are administered twice daily. For a formulation to be an effective and safe basal insulin, its action should be roughly the same every hour of the day. Currently, only insulin glargine U300 and insulin degludec meet this standard in dogs, whereas in cats, insulin glargine U300 is the closest option.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36906469/