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Peer-reviewed veterinary case report

Insulin Therapy in Small Animals, Part 3: Dogs.

Journal:
The Veterinary clinics of North America. Small animal practice
Year:
2023
Authors:
Fleeman, Linda & Gilor, Chen
Affiliation:
Animal Diabetes Australia · Australia
Species:
dog

Plain-English summary

Insulin therapy for dogs is designed to closely mimic how their bodies would normally produce insulin. There are several types of insulin that can be given twice a day, including Lente, NPH, and glargine, which help manage blood sugar levels without completely eliminating symptoms. The goal is to reduce signs of diabetes while being careful not to cause low blood sugar. Most dogs do well with just a long-acting insulin, but a few may need an extra dose of insulin during one meal to keep their blood sugar stable. Overall, this approach can effectively manage diabetes in dogs.

Abstract

Insulin therapy should ideally mimic a basal-bolus pattern. Lente, NPH, NPH/regular mixes, PZI, glargine U100, and detemir are intermediate-acting formulations that are administered twice daily in dogs. To minimize hypoglycemia, intermediate-acting insulin protocols are usually geared towards alleviating (but not eliminating) clinical signs. Insulin glargine U300 and insulin degludec meet the criteria for an effective and safe basal insulin in dogs. In most dogs, good control of clinical signs is achieved when using a basal insulin alone. In a small minority, bolus insulin at the time of at least one meal per day may be added to optimize glycemic control.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/36906466/