Peer-reviewed veterinary case report
How to adjust once-daily insulin glargine for diabetic dogs
By Tardo, Antonio Maria et al.·Published in Journal of veterinary internal medicine·2024·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
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Original publication title: A dose titration protocol for once-daily insulin glargine 300 U/mL for the treatment of diabetes mellitus in dogs.
- Species:
- dog
Plain-English summary
A group of 95 diabetic dogs were treated with a new insulin called insulin glargine 300 U/mL to help manage their blood sugar levels. Most of these dogs showed good to excellent control of their diabetes after starting treatment, with many receiving the insulin once a day. Some dogs needed extra doses at mealtime to keep their blood sugar stable. While the treatment was generally effective, a small number of dogs experienced low blood sugar. Overall, insulin glargine appears to be a promising option for managing diabetes in dogs.
People also search for: dog diabetes treatment · insulin glargine for dogs · managing dog blood sugar levels
Abstract
BACKGROUND: In purpose-bred dogs, insulin glargine 300 U/mL (IGla300) has long duration of action, peakless time-action profile, and low potency, making it suitable for use as a basal insulin. HYPOTHESIS: To evaluate IGla300 in client-owned diabetic dogs monitored using a flash glucose monitoring system (FGMS). ANIMALS: Ninety-five client-owned diabetic dogs, newly diagnosed or previously treated with other insulin formulations, with or without concurrent diseases. METHODS: Prospective multi-institutional study. Clinical signs and standardized assessment of FGMS data, using treatment and monitoring guidelines established a priori, guided dose adjustments and categorization into levels of glycemic control. RESULTS: The initial IGla300 dose was 0.5 U/Kg q24h for newly diagnosed dogs and (median dose [range]) 0.8 U/Kg (0.2-2.5) q24h for all dogs. Glycemic control was classified as good or excellent in 87/95 (92%) dogs. The IGla300 was administered q24h (1.9 U/kg [0.2-5.2]) and q12h (1.9 U/kg/day [0.6-5.0]) in 56/95 (59%) and 39/95 (41%) dogs, respectively. Meal-time bolus injections were added in 5 dogs (0.5 U/kg/injection [0.3-1.0]). Clinical hypoglycemia occurred in 6/95 (6%) dogs. Dogs without concurrent diseases were more likely to receive IGla300 q24h than dogs with concurrent diseases (72% vs 50%, respectively; P = .04). CONCLUSIONS AND CLINICAL IMPORTANCE: Insulin glargine 300 U/mL can be considered a suitable therapeutic option for once-daily administration in diabetic dogs. Clinicians should be aware of the low potency and wide dose range of IGla300. In some dogs, twice-daily administration with or without meal-time bolus injections may be necessary to achieve glycemic control. Monitoring with FGMS is essential for dose titration of IGla300.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38831362/