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Peer-reviewed veterinary case report

Cat with intestinal T-cell lymphoma and severe eosinophilia

By Takeuchi, Yoshinori et al.·Published in The Journal of veterinary medical science·2012·Department of Veterinary Internal Medicine, Japan·View original on PubMed

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Original publication title: Intestinal T-cell lymphoma with severe hypereosinophilic syndrome in a cat.

Species:
cat

Plain-English summary

An 8-year-old Japanese domestic long-hair cat was brought to the vet for vomiting and bloody diarrhea. Tests showed a high level of eosinophils, which are a type of white blood cell, and a diagnosis of intestinal T-cell lymphoma was made. Initially, the cat was treated with prednisolone and seemed stable, but after 512 days, it started vomiting blood, lost weight, and refused to eat. Unfortunately, the cat developed severe complications and passed away shortly after.

People also search for: cat vomiting blood · cat weight loss · cat intestinal lymphoma treatment · cat anorexia causes · hypereosinophilia in cats

Abstract

A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic with only prednisolone administration, the cat presented with hematemesis, weight loss, and severe anorexia 512 days after the initial presentation. Subsequently, gastrointestinal perforation developed, and the cat died on Day 536. Histopathological examination of autopsy specimens revealed mixed cellular infiltration including eosinophils and neoplastic lymphocytes in the intestinal lymph nodes, intestine, liver, spleen, and pancreas. Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22452876/