Peer-reviewed veterinary case report
Dog with mast cell tumor invading brain and neck bone
By Kingsbury, Edward et al.·Published in Veterinary medicine and science·2024·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Intracranial invasion of a mast cell tumour in a dog: A case report and review of the literature.
- Species:
- dog
Plain-English summary
An 11-year-old female beagle was brought in with a growing mass on the left side of her neck, which caused her face to look uneven. Tests showed that the mass was a mast cell tumor (a type of cancer) that had spread to nearby lymph nodes and her liver. The owner decided to treat her with medications, but before starting the treatment, the dog experienced severe seizures, leading to the difficult decision of euthanasia. A postmortem examination confirmed that the tumor had aggressively invaded surrounding tissues and even the brain.
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Abstract
An 11-year-old, female-neutered beagle was presented with a growing soft tissue mass arising within the deep tissues of the left cranial cervical region. At presentation, facial asymmetry was evident along with palpable lymphadenomegaly. Magnetic resonance imaging demonstrated a locally invasive cervical mass with intracranial invasion through focal osteolysis of the occipital bone. After antihistamine administration, cytology confirmed mast cell tumour (MCT) with metastasis to local lymph nodes and liver. The owner chose to pursue lomustine and prednisolone, which were dispensed, but, before home administration, prolonged seizures/status epilepticus occurred prompting euthanasia. Postmortem examination confirmed a high-grade MCT associated with, and infiltrating through, muscle, calvarium, dura mata, leptomeninges and the underlying brain. We present the clinical, imaging, and pathological findings of an unprecedented case of extracranial MCT tumour causing osteolysis of an imperforate flat bone (occipital bone) and intracranial invasion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38450948/