Peer-reviewed veterinary case report
Rare skin cancer in the perianal area of two cats
By Hargis, Ann M et al.·Published in Veterinary dermatology·2008·DermatoDiagnostics, United States·View original on PubMed →
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Original publication title: Intraepidermal adenocarcinoma in the perianal skin of two cats, a condition resembling human extramammary Paget's disease.
- Species:
- cat
Plain-English summary
A 10-year-old male domestic shorthair cat was brought in for a red, itchy rash around the anus, while another cat had a thickened area near the same spot. Both cats were otherwise healthy, but the first cat's skin lesions were concerning enough for further testing. The tests showed that the unusual skin cells were a type of cancer called intraepidermal adenocarcinoma, which is rare in cats. This finding is significant as it resembles a condition seen in humans. Treatment options were not detailed, but early detection is crucial for managing such conditions.
People also search for: cat anal skin rash · cat cancer symptoms · itchy skin around cat's anus · cat thickened anal area · cat skin tumor treatment
Abstract
In humans, mammary and extramammary Paget's disease is an uncommon to rare manifestation of intraepidermal adenocarcinoma arising from simple epithelium, usually glandular in origin. This report describes two cats with lesions in perianal skin consisting of atypical intraepidermal neoplastic cells. Differential diagnoses included intraepidermal adenocarcinoma, in situ squamous or basal cell carcinoma, junctional amelanotic melanoma, and epitheliotropic tumours of histiocytic or lymphocytic origin. The atypical intraepidermal cells in the cats were immunohistochemically positive for cytokeratin 8/18 (CK8/18), which stains simple (glandular) epithelium. The keratinocytes and basal cells were negative for CK8/18. In addition, the atypical intraepidermal cells were immunohistochemically negative for melanocytic, lymphocytic, and histiocytic markers. The staining results confirmed the atypical intraepidermal cells to be of simple glandular origin, and ruled out other causes of intraepidermal malignancy. In one cat the clinical lesions consisted of a pruritic erythematous eruption surrounding the anus. Another cat presented clinically for an area of irregular anal thickening; this cat had well-regulated diabetes mellitus. The cats were otherwise clinically healthy. The clinical features, histological appearance, and immunohistochemical staining of the skin lesions were consistent with those described for human perianal extramammary Paget's disease. To the authors' knowledge, this is the first report of an intraepidermal adenocarcinoma in a cat or other animal species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18177290/