Peer-reviewed veterinary case report
Dog with B-cell leukemia showing unusual cell inclusions
By Kato, Daiki et al.·Published in Veterinary clinical pathology·2016·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Intranuclear inclusions in a dog with B-cell leukemia.
- Species:
- dog
Plain-English summary
A 7-year-old Shetland Sheepdog was brought to the vet because it wasn't eating. Blood tests showed low platelet and white blood cell counts, and further examination of the bone marrow revealed a high number of abnormal cells linked to B-cell leukemia. The dog initially responded well to a multi-drug chemotherapy treatment and went into remission. Unfortunately, after about seven months, the cancer progressed, and the dog developed severe kidney problems, leading to its passing.
People also search for: dog not eating · Shetland Sheepdog leukemia treatment · dog kidney problems after chemotherapy
Abstract
A 7-year-old Shetland Sheepdog was presented with anorexia. A CBC indicated thrombocytopenia and neutropenia. Bone marrow cytology revealed that 67.7% of all nucleated cells (ANC) were anaplastic large mononuclear cells. These cells were confirmed to be of B-cell origin based on IgH rearrangement, immunohistochemical, and flow cytometric analysis. Microscopic examination revealed that the neoplastic cells had intranuclear inclusions resembling Dutcher bodies. Immunohistochemistry confirmed that the intranuclear inclusions were immunopositive for IgG antibodies. The periodic acid-Schiff reaction was negative for the presence of polysaccharides and related substances. Although the dog achieved complete remission with a multi-drug chemotherapy protocol, it ultimately died because of tumor progression and acute renal insufficiency on day 201. This is the first known case of canine acute B-cell leukemia with intranuclear inclusions resembling Dutcher bodies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27787912/