Peer-reviewed veterinary case report
Intraperitoneal chemo with COP drugs helps cats with lymphoma
By Teske, E et al.·Published in Veterinary and comparative oncology·2014·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Intraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide, vincristine and prednisolone protocol in cats with malignant lymphoma.
- Species:
- cat
Plain-English summary
A group of 26 cats with malignant lymphoma (a type of cancer) received chemotherapy through an injection into their abdomen instead of the usual intravenous method. This approach was less stressful for the cats and had a high success rate, with about 77% achieving complete remission. The cats that went into remission lived longer, with a median survival of about 388 days. Overall, this study suggests that giving chemotherapy through the abdomen is a safe and effective option for treating lymphoma in cats.
People also search for: cat lymphoma treatment · chemotherapy for cats · feline cancer survival rates · cat cancer remission · intraperitoneal chemotherapy for cats
Abstract
In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol-cyclophosphamide, vincristine and prednisolone (IP-COP) in 26 cats with malignant lymphoma. Certainly in cats fiercely resisting IV administration the IP route is a more practical method, safer for the administrator and less stressful for the cat. Complete remission (CR) rate was 76.9% (n = 20). Median duration of first remission was 421 days. Estimated 1- and 2-year disease free period were 67.1 and 48.0%, respectively. Median duration of survival was 388 days and estimated overall 1- and 2-year survival periods were 54.7 and 46.9% respectively. Young cats had a more favourable prognosis. Reaching CR was essential for long-term survival. No specific IP-related adverse events (AE) were seen. AE were generally scored as mild and were not excessively abundant. These results indicate that the IP route is a safe and effective alternative for the administration of COP protocol chemotherapeutics.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22489828/