Peer-reviewed veterinary case report
Electrochemogenetherapy with bleomycin and IL-12 treats dog head
By Cutrera, Jeffry et al.·Published in Methods in molecular biology (Clifton, N.J.)·2008·Department of Comparative Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with head and neck tumors received a combination treatment of Bleomycin (a chemotherapy drug) and Interleukin 12 (a protein that helps fight cancer) followed by a procedure called electroporation to enhance the effects. Within two weeks, the main tumor was completely gone, and after 23 weeks, the nearby bone tumor was also no longer visible on scans. This approach showed promising results in shrinking tumors in dogs with these types of cancers.
People also search for: dog head and neck tumor treatment · Bleomycin for dogs cancer · electroporation in dogs
Abstract
Bleomycin and Interleukin 12 have been used clinically to treat tumors; however, the co-administration of Bleomycin and Interleukin 12 followed by electroporation has not been tested clinically. In this study, dogs with spontaneous head and neck tumors were treated with one co-administration of Bleomycin and Interleukin 12 plasmid DNA followed by electroporation. The regression of the recurrent papillary tumor and the adjacent metastatic bone tumor was analyzed by multiple CT scans. The papillary tumor was completely eradicated in less than 2 weeks, and the bone tumor was not visible 23 weeks after the administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18370210/