Peer-reviewed veterinary case report
Temozolomide microcylinders implanted in dogs with brain tumors
By Hicks, Jill et al.·Published in Veterinary medicine and science·2019·Veterinary Teaching Hospital, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders.
- Species:
- dog
Plain-English summary
Four dogs with brain tumors called gliomas were treated with a new method involving tiny drug-filled cylinders implanted directly into their tumors. These dogs had been experiencing generalized seizures but had only mild neurological issues when they underwent surgery to place the microcylinders. After the procedure, all dogs recovered well, showing that this new treatment is safe and can be tolerated. Future studies will look at how effective this treatment is over the long term.
People also search for: dog brain tumor treatment · canine glioma seizures · temozolomide for dogs · dog surgery recovery after brain tumor
Abstract
Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. All four dogs presented with generalized seizures and had mild to no neurologic deficits at the time of craniotomy. All dogs underwent craniotomy for implantation of the microcylinders into partially resected gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma {n = 3}). All dogs recovered well from the craniotomy and implantation procedure. This novel procedure appears to be feasible and tolerated in tumour-bearing dogs. A future controlled clinical study can now aim to evaluate the microcylinder implantation for long-term efficacy.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30394686/