Peer-reviewed veterinary case report
Dog with neurological signs diagnosed with intravascular lymphoma
By Rafael R. M. E. Costa et al.·Published in Brazilian Journal of Veterinary Pathology·2020·Discente do curso de graduação em Medicina Veterinária, Faculdade de Ciências Agrárias e Veterinárias (FCAV-Unesp Jaboticabal), Jaboticabal, SP, Brasil., BR·View original on DOAJ →
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Original publication title: Intravascular lymphoma in a dog: case report
- Species:
- dog
Plain-English summary
A mixed-breed dog, 8 years old, was brought in showing neurological signs, which led the vet to suspect a serious condition. Unfortunately, after the dog passed away, a necropsy revealed intravascular lymphoma, a type of cancer where abnormal lymphocytes grow inside blood vessels, affecting various organs including the brain and spleen. The diagnosis was challenging because typical tests were inconclusive, but the presence of these cancerous cells was confirmed through specialized lab tests. This case highlights the importance of considering intravascular lymphoma when dogs show neurological symptoms.
People also search for: dog neurological signs · intravascular lymphoma in dogs · mixed breed dog cancer symptoms
Abstract
Intravascular lymphoma is characterized by being a malignant neoplasm of extranodal T or B lymphocytes with exclusive proliferation within the vascular lumen, particularly of small vessels. The clinical signs vary due to the involvement of several organs, mainly the central nervous system. The diagnosis is difficult because many of the tests performed are not conclusive and, therefore, necropsy is the most efficient way to identify this tumor. This case report aims to describe the anatomopathological findings of a case of intravascular lymphoma in a mixed breed, 8 years old dog who presented neurological signs and was submitted to a necroscopic examination with clinical suspicion of granulomatous meningoencephalitis. The necropsy findings were not specific, but the presence of intravascular neoplastic lymphocytes in the brain, spleen, adrenal gland and stomach was verified by microscopy. These cells were positive for the CD3 antibody by immunohistochemistry, confirming the T lymphocyte phenotype. This neoplasm should be considered in the diagnosis of encephalopathies in dogs.
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Search related cases →Original publication on DOAJ: https://doi.org/10.24070/bjvp.1983-0246.v13i2p545-548