Peer-reviewed veterinary case report
Intravascular tumor cells found in dog skin plasmacytomas and what it
By Ehrensing, Gordon & Craig, Linden E·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Intravascular neoplastic cells in canine cutaneous plasmacytomas.
- Species:
- dog
Plain-English summary
A study looked at skin tumors called cutaneous plasmacytomas in 125 dogs, mostly middle-aged to older, to see if certain tumor characteristics affected their outcome. The researchers found that 16% of the dogs had tumor cells inside blood vessels, but this did not seem to change the dogs' prognosis. Most dogs did not have any serious issues related to these tumors, and only one dog had a recurrence of the tumor. Overall, the presence of tumor cells in blood vessels did not appear to impact the dogs' health or survival.
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Abstract
We evaluated 134 cutaneous plasmacytomas in 125 dogs submitted to the University of Tennessee surgical biopsy service between 2009 and 2012 to determine whether the presence of intravascular neoplastic cells had prognostic significance. Tumors occurred in middle-aged to geriatric dogs (range: 5-16 y, mean: 9.6 y) and most frequently involved the skin of the head and distal limbs. Diagnoses were made based on light microscopy, and in some cases confirmed by immunoreactivity of neoplastic cells for MUM1. Tumors were categorized as having or not having intravascular neoplastic cells within sections examined. The intravascular location of tumor cells was confirmed by immunoreactivity of endothelial cells for factor VIII-related antigen in 3 cases. Neoplastic cells within vessel lumens were identified in 20 of 125 dogs (16%). Submitting veterinary practices were contacted for follow-up data on patients including local recurrence and cutaneous plasmacytomas in other locations. Follow-up information was acquired on 99 dogs (79%). Recurrence was documented in one dog with cutaneous plasmacytomas; both masses had incomplete margins and intravascular neoplastic cells. Additional distant cutaneous plasmacytomas were later diagnosed in 3 patients; none of these dogs had intravascular neoplastic cells. In no cases were cutaneous plasmacytomas suspected to be a cause of death or reason for euthanasia. Intravascular neoplastic cells were more common in tumors of the distal limbs (36%) compared to other locations (11%; p = 0.0007). The presence of intravascular neoplastic cells did not affect prognosis in cutaneous plasmacytomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29291682/