Peer-reviewed veterinary case report
Hypercoagulability risk during immune thrombocytopenia treatment
By O'Marra, Shana K et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2012·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Investigating hypercoagulability during treatment for immune-mediated thrombocytopenia: a pilot study.
- Species:
- dog
Plain-English summary
A group of dogs with immune-mediated thrombocytopenia (ITP), a condition that causes low platelet counts and can lead to bleeding, was monitored to see if they developed blood clotting issues during treatment. Initially, all the dogs showed signs of poor clotting ability, but as treatment progressed, tests indicated that they became more prone to forming clots. This change suggests that while the dogs were recovering, they might also face a risk of blood clots, although the exact clinical implications are still unclear.
People also search for: dog ITP treatment · immune-mediated thrombocytopenia in dogs · dog blood clotting issues
Abstract
BACKGROUND: Thromboembolism has recently been described as a complication following treatment for idiopathic thrombocytopenic purpura (ITP). This pilot study was undertaken to determine whether dogs suffering from ITP experience hypercoagulability during treatment and recovery. STUDY DESIGN: Thromboelastograms (TEG) were performed on dogs with ITP within 24 hours of admission to the hospital, the first day the platelet count exceeded 40 × 10(9) /L (Day 1), and on Days 4, 7, and 14. KEY FINDINGS: All dogs had hypocoagulable TEG tracings on initial admission to the hospital, but developed TEG tracings suggestive of hypercoagulability during the study period as indicated by increased maximum amplitude. SIGNIFICANCE: Dogs with ITP developed changes on TEG consistent with hypercoagulability during the study period. Many factors are likely to contribute to these changes. The clinical risk of thrombosis in these patients is unknown.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22316313/