Peer-reviewed veterinary case report
Canine parvovirus outbreak in Alaska dogs studied with gene sequencing
By Parker, Jayme et al.·Published in Scientific reports·2017·Department of Biology and Wildlife, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Investigation of a Canine Parvovirus Outbreak using Next Generation Sequencing.
- Species:
- dog
Plain-English summary
A group of dogs in Alaska showed signs of severe illness during a parvovirus outbreak in the winter of 2016. Twelve dogs from local mushing kennels were tested, and all were found to have canine parvovirus (CPV), which can be deadly if not treated. The investigation revealed that the outbreak likely occurred because some dogs were not vaccinated or were under-vaccinated, rather than due to a new strain of the virus. Vaccination is crucial to prevent such outbreaks and protect dogs from this serious disease.
People also search for: dog parvovirus symptoms · why is my dog sick after vaccination · canine parvovirus treatment
Abstract
Canine parvovirus (CPV) outbreaks can have a devastating effect in communities with dense dog populations. The interior region of Alaska experienced a CPV outbreak in the winter of 2016 leading to the further investigation of the virus due to reports of increased morbidity and mortality occurring at dog mushing kennels in the area. Twelve rectal-swab specimens from dogs displaying clinical signs consistent with parvoviral-associated disease were processed using next-generation sequencing (NGS) methodologies by targeting RNA transcripts, and therefore detecting only replicating virus. All twelve specimens demonstrated the presence of the CPV transcriptome, with read depths ranging from 2.2X - 12,381X, genome coverage ranging from 44.8-96.5%, and representation of CPV sequencing reads to those of the metagenome background ranging from 0.0015-6.7%. Using the data generated by NGS, the presence of newly evolved, yet known, strains of both CPV-2a and CPV-2b were identified and grouped geographically. Deep-sequencing data provided additional diagnostic information in terms of investigating novel CPV in this outbreak. NGS data in addition to limited serological data provided strong diagnostic evidence that this outbreak most likely arose from unvaccinated or under-vaccinated canines, not from a novel CPV strain incapable of being neutralized by current vaccination efforts.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28852158/