Peer-reviewed veterinary case report
Link between blood inflammation protein and protein in dog urine
By Ruane, E et al.Ā·Published in The Journal of small animal practiceĀ·2026Ā·Department of Veterinary Medicine, United KingdomĀ·View original on PubMed ā
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research ā every detail traces back to the citation above. How we work ā
Original publication title: Investigation of association between serum C-reactive protein concentrations and proteinuria in dogs.
- Species:
- dog
Plain-English summary
A study found that dogs with high levels of protein in their urine (proteinuria) often had underlying health issues, particularly chronic hepatitis or pancreatitis. In contrast, dogs with chronic enteropathy (a type of intestinal disease) were less likely to have proteinuria. The research also indicated that higher serum C-reactive protein levels, which signal inflammation, were linked to increased chances of proteinuria. This suggests that inflammation in the body might be connected to kidney issues in dogs. More research is needed to see if treating the underlying conditions can help reduce protein levels in urine.
People also search for: dog protein in urine causes Ā· dog chronic hepatitis treatment Ā· dog pancreatitis symptoms
Abstract
OBJECTIVES: Identify if serum C-reactive protein concentrations and specific diseases are associated with proteinuria (defined as urine protein:creatinine ratio >0.2) in dogs without known pathological pre-renal, renal or post-renal causes. MATERIALS AND METHODS: Hypothesis generating retrospective study. Dogs with contemporaneous urine protein:creatinine ratio and serum C-reactive protein concentrations and without known causes of pathological pre-renal, renal or post-renal causes of proteinuria were included. Continuous and categorical variables were compared between groups using non-parametric statistics, and multivariable logistic regression analyses evaluated associations between specific diseases or selected clinicopathological variables (including serum C-reactive protein concentrations) and proteinuria. RESULTS: Seventy-one overtly proteinuric (urine protein:creatinine ratio >0.5), 74 borderline proteinuric (urine protein:creatinine ratio 0.21 to 0.5) and 234 non-proteinuric dogs (urine protein:creatinine ratio ≤.2) were included. Proteinuria (urine protein:creatinine ratio >0.2) was less prevalent in dogs diagnosed with chronic enteropathy (11% [4/35] vs. 41% [141/344]; P < .001) compared to the rest of the population. Proteinuria was more prevalent in dogs with chronic hepatitis (71% [10/14] vs. 37% [135/365]) and tended to be more prevalent in dogs with pancreatitis (57% [12/21] vs. 37% [133/358]; P = .103) compared to the rest of the population. On multivariable analysis, serum C-reactive protein concentration was independently associated with increased odds of proteinuria (OR = 1.031 [95% CI: 1.012 to 1.051]; P = .001) and a diagnosis of chronic enteropathy was independently associated with decreased odds of proteinuria (OR = 0.21 [95% CI: 0.064 to 0.681]; P = .009). CLINICAL SIGNIFICANCE: Systemic inflammation might be associated with proteinuria in dogs, although further investigations to evaluate if proteinuria resolves following the resolution of these conditions are required to confirm any causal association.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41162828/