Peer-reviewed veterinary case report
Serum protein changes linked to kidney disease in hyperthyroid cats
By Williams, Tim L et al.·Published in Research in veterinary science·2017·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats were studied to see if their blood protein levels changed and if this was linked to kidney problems after treatment. The researchers found that these cats had higher levels of one type of protein and lower levels of another compared to healthy cats. After treatment, the overall protein levels increased, and the specific protein levels adjusted as well. However, these changes in protein levels did not seem to relate to whether the cats developed kidney disease later on.
People also search for: hyperthyroid cat symptoms · cat kidney disease treatment · changes in cat blood protein levels
Abstract
Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment. Initially non-azotaemic hyperthyroid cats and healthy older cats were included. Serum concentrations of protein fractions were determined by agarose gel electrophoresis and compared between; hyperthyroid and control cats, initially non-azotaemic hyperthyroid cats which developed azotaemia in a 4month follow up period (masked-azotaemic) and those which remained non-azotaemic, and hyperthyroid cats before and at the time of restoration of euthyroidism. Data are presented as median [25th, 75th percentiles]. Hyperthyroid cats (n=56) had higher serum αglobulin concentrations (12.5 [10.9, 13.1] g/L vs. 9.8 [3.0, 11.4] g/L; P<0.001) and lower serum γ globulin concentrations (11.4 [9.1, 13.3] g/L vs. 14.0 [12.4, 16.8] g/L; P=0.001) than control cats (n=26). Following treatment, serum total globulin concentration increased (from 38.6 [35.4, 42.8] g/L to 42.3 [39.0, 45.7] g/L; P<0.001), serum αglobulin concentration decreased (from 12.5 [10.9, 13.9] g/L to 11.5 [10.1, 12.6] g/L; P<0.001) and serum γ globulin concentration increased (from 11.4 [9.0, 13.3] g/L to 14.0 [12.4, 16.8] g/L; P<0.001). Serum concentrations of total globulin or globulin fractions were not significantly different between masked-azotaemic and non azotaemic groups. In conclusion, hyperthyroidism is associated with altered serum concentrations of the αand γ globulin fractions, however these changes were not associated with the development of azotaemic chronic kidney disease following treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28753515/