Peer-reviewed veterinary case report
Flavopiridol drug kills canine lymphoma cells by causing apoptosis
By Ema, Y et al.·Published in Veterinary and comparative oncology·2016·Joint Faculty of Veterinary Medicine, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Investigation of the cytotoxic effect of flavopiridol in canine lymphoma cell lines.
- Species:
- dog
Plain-English summary
A study tested a new cancer treatment called flavopiridol on dogs with lymphoma, a type of cancer affecting the lymphatic system. In lab tests, flavopiridol caused significant cell death in all tested lymphoma cell lines, indicating it could be effective in treating this cancer. When used in mice with transplanted canine lymphoma cells, the treatment led to noticeable tumor shrinkage. This suggests that flavopiridol might be a promising option for dogs diagnosed with lymphoma, potentially improving their chances of recovery.
People also search for: dog lymphoma treatment · flavopiridol for canine cancer · lymphoma in dogs symptoms
Abstract
The cyclin-dependent kinase (CDK) inhibitor, flavopiridol, was tested as a potential new cancer therapeutic agent to treat canine lymphoma by examining its effect on cell growth of canine lymphoma cell lines in vitro. Flavopiridol induced profound cell death in all eight lymphoma cell lines at 400 nM, and in all cases cell death was due to apoptosis. Apoptosis was inhibited by caspase inhibitor, despite the variable sensitivities between cell lines. Analysis of the mechanism of flavopiridol-induced apoptosis showed that Rb phosphorylation was inhibited, possibly due to CDK4 or CDK6 inhibition. There was also decreased expression of Rb protein and anti-apoptotic proteins, Mcl-1 and XIAP, possibly through transcriptional regulation by inhibition of CDK7 or CDK9 activation. Canine lymphoma cell line-xenotransplanted mice were then treated with flavopiridol and profound tumour shrinkage was observed. This study describes a new therapeutic approach using flavopiridol for canine lymphoma treatment.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25623777/