Peer-reviewed veterinary case report
Kidney damage signs in dogs after single-dose cisplatin chemo
By Maghsoudi, Omid et al.·Published in Diagnostic pathology·2015·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Investigations of renal function using the level of neutrophil gelatinase-associated lipocalin associated with single-dose of cisplatin during chemotherapy.
- Species:
- dog
Plain-English summary
A group of dogs with kidney tumors received a chemotherapy drug called cisplatin, and some showed signs of kidney injury. Researchers measured levels of a protein called NGAL in their blood and urine to see how well their kidneys were functioning. The dogs treated with cisplatin had higher levels of NGAL, indicating kidney stress, especially those with existing kidney issues. This suggests that monitoring NGAL levels could help veterinarians identify and manage kidney damage caused by chemotherapy in dogs.
People also search for: dog kidney cancer treatment · cisplatin side effects in dogs · monitoring kidney function in dogs
Abstract
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is known as a primary indicator of acute and chronic renal and can be effective in chronic kidney injury (CKI) with kidney tumors cisplatin (CP) chemotherapy. The aim of this study was to evaluate serum and urinary biomarker including NGAL (sNGAL and uNGAL) in canine with solid renal tumors who suffered from cisplatin after short and long-term chemotherapy. METHODS: In this study, in treatment and control groups, canine (n = 10 and n = 5) were administered cisplatin at 1.2 mg/kg/day (i.v.) for five consecutive days with CKI and without CKI, respectively. Serum and urine NGAL levels (ng/mL) were evaluated at 0, 1, 5, 9, 13, 17, 21, 25 and 29 days after drug injection versus baseline in treated and control groups. RESULTS: Canine in treatment group had shown symptoms of toxicity of cisplatin. The results indicated the higher concentrations of serum, sNGAL and uNGAL (P = 0.024; P = 0.011) compared with control group (P = 0.701, P = 0.612), (Table 2, Figs. 1 and 2). Indeed, our results showed that canine with CKI were associated with higher levels of sNGAL and uNGAL compared with control group without CKI. Moreover, the highest level of uNGAL was seen in comparison with sNGAL, after a high dose (1.2 mg/kg) administration of CP. CONCLUSION: Our data suggested that U-NGAL may be useful for monitoring of renal injury in CKI patients that exposed with cisplatin. Furthermore, a primary elevate in urinary NGAL expulsion may help in identifying cases at danger of cisplatin-induced CKI that might profit from innovative remedies to prevent cisplatin nephrotoxicity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26170013/