Peer-reviewed veterinary case report
Is inflammatory bowel disease in dogs and cats associated with a Th1 or Th2 polarization?
- Journal:
- Veterinary immunology and immunopathology
- Year:
- 2015
- Authors:
- Heilmann, Romy M & Suchodolski, Jan S
- Affiliation:
- Department of Small Animal Clinical Sciences · United States
Abstract
Mucosal immunity involves complex interactions to generate either immune tolerance or active immune responses. An imbalance of pro- and anti-inflammatory cytokines and chemokines that drive the recruitment of immune cells to the intestinal mucosa are a key characteristic of inflammatory bowel disease in humans, where distinctive helper-T-lymphocyte profiles help to discriminate between Crohn's disease and ulcerative colitis. This review evaluates the current veterinary literature to determine whether a Th1/Th2 (and possibly also Th17) polarization also exists in canine and feline inflammatory bowel disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26672910/