Peer-reviewed veterinary case report
PTEN gene variant linked to mammary tumors in female dogs
By Canadas-Sousa, Ana et al.·Published in International journal of molecular sciences·2025·Department of Pathology and Molecular Immunology·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Is PTEN rs397510595 an Unexpected Guardian in Canine Mammary Neoplasia?
- Species:
- dog
Plain-English summary
A study looked at 206 female dogs with mammary tumors to see how certain genetic factors might affect their health. They found that a specific genetic variant (PTEN rs397510595) was linked to dogs being diagnosed at an older age (11 years or older) and having better survival rates. Dogs with this variant had an average survival of 22.2 months compared to 19.5 months for those without it. This suggests that this genetic marker could help predict how well a dog with mammary tumors might do in the long run.
People also search for: dog mammary tumor survival rate · canine breast cancer genetics · PTEN gene in dogs
Abstract
Despite steps having been taken to study the influence of genetic polymorphisms in canine mammary neoplasia, the knowledge of their relevance is still incipient compared to the knowledge of human breast cancer. Among tumor suppressor genes, PTEN plays a pivotal role in carcinogenesis; however, the contribution of its constitutional variants to the biology of canine mammary neoplasia remains poorly understood. This observational study assessed the association between PTEN SNPs rs397510595 and rs397513087, genotyped from peripheral blood, and the clinicopathological features, including survival, in a cohort of 206 female dogs with mammary neoplasia. The minor A allele of rs397510595 was present in 17.5% of the population. Carriers of the variant allele were more frequently diagnosed at a late age ≥ 11 years, displayed a complete absence of vascular invasion, and exhibited significantly longer overall survival (mean 22.2 vs. 19.5 months). The SNP rs397513087 did not show a significant association with clinicopathological features or survival. Our data suggests that SNP rs397510595 of the PTEN gene is a putative protective factor for developing canine mammary neoplasia at an early age and might be used as a biomarker for prognostic assessment in dogs with malignant mammary neoplasia.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41226689/