Peer-reviewed veterinary case report
Estrogen receptor gene types linked to dog mammary tumors
By Canadas-Sousa, Ana et al.·Published in BMC veterinary research·2019·Department of Pathology and Molecular Immunology·View original on PubMed →
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Original publication title: Estrogen receptors genotypes and canine mammary neoplasia.
- Species:
- dog
Plain-English summary
A group of 155 female dogs with mammary tumors was studied to see how certain genetic factors might affect the tumors' characteristics and progression. The findings indicated that some genetic profiles were linked to tumors that appeared later in life and were less aggressive, often being smaller and showing better differentiation. This suggests that understanding a dog's genetic makeup could help veterinarians recommend personalized prevention strategies, like early spaying, to reduce the risk of developing mammary tumors.
People also search for: dog mammary tumor genetics · spaying dogs to prevent cancer · canine mammary tumor treatment options
Abstract
BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. RESULTS: Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. CONCLUSIONS: Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31506083/