Peer-reviewed veterinary case report
Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2016
- Authors:
- Wiederhold, Nathan P et al.
- Affiliation:
- University of Texas Health Science Center at San Antonio · United States
- Species:
- rodent
Abstract
We evaluated the efficacy of isavuconazole against cryptococcal meningitis. Treatment with either oral isavuconazole (120 mg/kg and 240 mg/kg twice a day [BID]) or fluconazole as the positive control significantly improved survival in mice infected intracranially with either Cryptococcus neoformans USC1597 or H99 and significantly reduced brain fungal burdens for both isolates. Concentrations of isavuconazole in plasma and brain tissue also demonstrated that the greatest improvements in survival and fungal burden were associated with elevated exposures.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27324761/