Peer-reviewed veterinary case report
Dog with kidney disease and high cortisol treated for low aldosterone
By Park, Su-Min et al.·Published in Veterinary medicine and science·2022·Department of Veterinary Clinical Science, South Korea·View original on PubMed →
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Original publication title: Isolated hypoaldosteronism managed by DOCP in a dog with chronic kidney disease and hypercortisolism.
- Species:
- dog
Plain-English summary
A 13-year-old female Schnauzer was brought in with serious electrolyte imbalances, including high potassium and low sodium levels, due to isolated hypoaldosteronism (a condition where the body doesn't produce enough aldosterone). This dog also had chronic kidney disease and other health issues. After testing, the vet treated her with a medication called deoxycorticosterone pivalate (DOCP), which successfully corrected her electrolyte levels. The dog's condition improved significantly after treatment, showing the importance of monitoring hormone levels in pets with chronic health issues.
People also search for: dog electrolyte imbalance treatment · Schnauzer kidney disease management · hypoaldosteronism in dogs
Abstract
A 13-year-old spayed female Schnauzer dog with chronic kidney disease (CKD; International Renal Interest Society stage 2, non-proteinuric, normotensive), diabetes mellitus, hypercortisolism and myxomatous mitral valve degeneration (American College of Veterinary Internal Medicine stage B2) presented with electrolyte imbalance that had progressed to hyperkalaemia and hyponatremia, with a sodium to potassium (Na:K) ratio of 19.6. Cortisol levels after the adrenocorticotropic hormone stimulation test were within the therapeutic range, but aldosterone levels were below the reference range; hence, isolated hypoaldosteronism was diagnosed. After administration of deoxycorticosterone pivalate (DOCP), the electrolyte imbalance improved with a Na:K ratio of 27.7. This is the first report of the management of isolated hypoaldosteronism and hypercortisolism using trilostane and DOCP in a dog. This case highlights the importance of recognizing isolated hypoaldosteronism after long-term treatment with trilostane in a canine patient with CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36106511/